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Neuro Endocrinol Lett 28:861867 Maes M, Mihaylova I, Kubera M et al (2009) Coenzyme Q10 deficiency in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is related to fatigue, autonomic and neurocognitive symptoms and is another risk factor explaining the early mortality in ME/CFS due to cardiovascular disorder

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In this issue of the JCI , Farokhnia and colleagues used a reverse translational approach to examine the effects of enhancing GLP-1R activity either through synthetic agonists or inhibition of its degrading enzyme, dipeptidyl peptidase-4 (DPP-4) on alcohol consumption in both humans and preclinical models (Figure 1) (4)